Roles of the C.elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates

被引：39

作者：

Belfiore, M ^{[1
]}

Pugnale, P ^{[1
]}

Saudan, Z ^{[1
]}

Puoti, A ^{[1
]}

机构：

[1] Univ Fribourg, Dept Biol, Unit Zool, CH-1700 Fribourg, Switzerland

来源：

DEVELOPMENT | 2004年 / 131卷 / 12期

关键词：

Cyclophilin; mog-6; fem-3; gld-3; mep-1; Germline development;

D O I：

10.1242/dev.01154

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The switch from spermatogenesis to oogenesis in the Caenorhabditis elegans hermaphrodite requires mog-6, which post-transcriptionally represses the fem-3 RNA. In this study, we show that mog-6 codes for a divergent nuclear cyclophilin, in that a conserved domain is not required for its function in the sperm-oocyte switch. MOG-6 binds to the nuclear zinc finger protein MEP-1 through two separate domains that are essential for the role of MOG-6 in the sperm-oocyte switch. We propose that MOG-6 has a function distinct from that of prevailing cyclophilins and that its binding to MEP-1 is essential for germline sex determination. Finally, we found that gld-3 mog-6 mutants develop germline tumors, suggesting that mog-6 might function in the decision between mitosis and meiosis.

引用

页码：2935 / 2945

页数：11

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