Effects of infiltrating lymphocytes and estrogen receptor on gene expression and prognosis in breast cancer

被引：104

作者：

Calabro, Alberto ^{[1
]}

Beissbarth, Tim ^{[1
]}

Kuner, Ruprecht ^{[1
]}

Stojanov, Michael ^{[1
]}

Benner, Axel ^{[2
]}

Asslaber, Martin ^{[3
]}

Ploner, Ferdinand

Zatloukal, Kurt ^{[3
]}

Samonigg, Hellmut

Poustka, Annemarie ^{[1
]}

Sueltmann, Holger ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Mol Genome Anal, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, Div Biostat, D-69120 Heidelberg, Germany

[3] Med Univ Graz, Inst Pathol, A-8036 Graz, Austria

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2009年 / 116卷 / 01期

关键词：

Breast cancer; Computational microdissection; Prognosis; Lymphocyte infiltration; Estrogen receptor; IMMUNE-RESPONSE; T-CELLS; TUMOR; SURVIVAL; INFLAMMATION; CARCINOMAS; IDENTIFICATION; ONTOLOGIES; SIGNATURES; RESOURCE;

D O I：

10.1007/s10549-008-0105-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The involvement of the immune system for the course of breast cancer, as evidenced by varying degrees of lymphocyte infiltration (LI) into the tumor is still poorly understood. The aim of this study was to evaluate the prognostic value of LI in breast cancer samples using microarray-based screening for LI-associated genes. Starting from the observation that most published ER gene signatures are heavily influenced by the LI effect, we developed and applied a novel approach to dissect molecular signatures. Further, a meta-analysis encompassing 1,044 hybridizations showed that LI alone is not sufficient to highlight breast cancer patients with different prognosis. However, for ER positive patients, high LI was associated with shorter survival times, whereas for ER negative patients, high LI is significantly associated with longer survival. Annotation of LI, in addition to ER status, is important for breast cancer patient prognosis and may have implications for the future treatment of breast cancer.

引用

页码：69 / 77

页数：9

共 44 条

[1] LYMPHOCYTE INFILTRATES AS A PROGNOSTIC VARIABLE IN FEMALE BREAST-CANCER [J].

AALTOMAA, S ;

LIPPONEN, P ;

ESKELINEN, M ;

KOSMA, VM ;

MARIN, S ;

ALHAVA, E ;

SYRJANEN, K .

EUROPEAN JOURNAL OF CANCER, 1992, 28A (4-5) :859-864

[2] High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates [J].

Alexe, Gabricla ;

Dalgin, Gul S. ;

Scanfeld, Daniel ;

Tamayo, Pablo ;

Mesirov, Jill P. ;

DeLisi, Charles ;

Harris, Lyndsay ;

Barnard, Nicola ;

Martel, Maritza ;

Levine, Arnold J. ;

Ganesan, Shridar ;

Bhanot, Gyan .

CANCER RESEARCH, 2007, 67 (22) :10669-10676

[3] Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development [J].

Aspord, Caroline ;

Pedroza-Gonzalez, Alexander ;

Gallegos, Mike ;

Tindle, Sasha ;

Burton, Elizabeth C. ;

Su, Dan ;

Marches, Florentina ;

Banchereau, Jacques ;

Palucka, A. Karolina .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (05) :1037-1047

[4]

Asslaber Martin, 2007, Briefings in Functional Genomics & Proteomics, V6, P193, DOI 10.1093/bfgp/elm023

[5] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[6] Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse [J].

Bates, Gaynor J. ;

Fox, Stephen B. ;

Han, Cheng ;

Leek, Russell D. ;

Garcia, Jose F. ;

Harris, Adrian L. ;

Banham, Alison H. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (34) :5373-5380

[7] GOstat: find statistically overrepresented Gene Ontologies within a group of genes [J].

Beissbarth, T ;

Speed, TP .

BIOINFORMATICS, 2004, 20 (09) :1464-1465

[8] Gene expression profiling shows medullary breast cancer is a subgroup of basal breast cancers [J].

Bertucci, Francois ;

Finetti, Pascal ;

Cervera, Nathalie ;

Charafe-Jauffret, Emmanuelle ;

Mamessier, Emilie ;

Adelaide, Jose ;

Debono, Stephane ;

Houvenaeghel, Gilles ;

Maraninchi, Dominique ;

Viens, Patrice ;

Charpin, Colette ;

Jacquemier, Jocelyne ;

Birnbaum, Daniel .

CANCER RESEARCH, 2006, 66 (09) :4636-4644

[9] Oncogenic pathway signatures in human cancers as a guide to targeted therapies [J].

Bild, AH ;

Yao, G ;

Chang, JT ;

Wang, QL ;

Potti, A ;

Chasse, D ;

Joshi, MB ;

Harpole, D ;

Lancaster, JM ;

Berchuck, A ;

Olson, JA ;

Marks, JR ;

Dressman, HK ;

West, M ;

Nevins, JR .

NATURE, 2006, 439 (7074) :353-357

[10]

Biswas D K., 2005, Sci. Signal, pp, DOI [DOI 10.1126/STKE.2882005PE27, https://doi.org/10.1126/stke.2882005pe27]

← 1 2 3 4 5 →