Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock: Implications for nutrition during manned space flight

被引:41
作者
Cassone, VM [1 ]
Stephan, FK
机构
[1] Texas A&M Univ, Dept Biol, Ctr Biol Clock Res, College Stn, TX 77843 USA
[2] Florida State Univ, Dept Psychol, Program Neurosci, Tallahassee, FL 32306 USA
关键词
circadian; suprachiasmatic nucleus; liver;
D O I
10.1016/S0899-9007(02)00937-1
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Circadian clocks have evolved to predict and coordinate physiologic processes with the rhythmic environment on Earth. Space studies in non-human primates and humans have suggested that this clock persists in its rhythmicity in space but that its function is altered significantly in long-term space flight, Under normal circumstances, the clock is synchronized by the light-dark cycle via the retinohypothalamic tract and the suprachiasmatic nucleus. It is also entrained by restricted feeding regimes via a suprachiasmatic nucleus-independent circadian oscillator. The site of this suboscillator (or oscillators) is not known, but new evidence has suggested that peripheral tissues in the liver and viscera may express circadian clock function when forced to do so by restricted feeding schedules or other homeostatic disruptions. New research on the role of the circadian clock in the control of feeding on Earth and in space is warranted. (C)Elsevier Science Inc. 2002.
引用
收藏
页码:814 / 819
页数:6
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