Primary adenosquamous carcinoma of the colon: Report of five cases

被引：30

作者：

Dong, Yingchun ^{[2
]}

Wang, Jiandong ^{[1
]}

Ma, Henghui ^{[1
]}

Zhou, Hangbo ^{[1
]}

Lu, Guangming ^{[1
]}

Zhou, Xiaojun ^{[1
]}

机构：

[1] Nanjing Jinling Hosp, Dept Pathol, Nanjing 210002, Peoples R China

[2] Nanjing Univ, Nanjing Stomatol Hosp, Dept Anesthesiol, Nanjing 210008, Peoples R China

来源：

SURGERY TODAY | 2009年 / 39卷 / 07期

关键词：

Colorectal carcinoma; Primary adenosquamous carcinoma; Human papilloma virus; P16; Prognosis; SQUAMOUS-CELL CARCINOMA; OF-THE-LITERATURE; HUMAN-PAPILLOMAVIRUS; UPPER RECTUM; HIGH-RISK; EXPRESSION; CANCER; P16;

D O I：

10.1007/s00595-008-3884-6

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Primary adenosquamous cell carcinomas (Ad-SCCs) of the colon and rectum are rare malignancies with a poor prognosis, in comparison to adenocarcinoma alone. Different roles of human papilloma virus (HPV) in its pathogenesis have been reported and the role of P16 in Ad-SCCs has not been explored. This report presents five cases of Ad-SCC of the colon to explore the clinicopathological features and the roles of P16, HPV 6/11, and 16/18. There was no confirmed evidence to support the relationship between the infection of HPV 6/11, 16/18, and pathogenesis of Ad-SCC of the colon. P16 overexpression was not related to HPV carcinogenesis and there might be another mechanism of P16 upregulation in Ad-SCC of the colon.

引用

页码：619 / 623

页数：5

共 22 条

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p16INK4a expression correlates with degree of cervical neoplasia:: A comparison detection of high-risk with Ki-67 expression and HPV types [J].