Anti-mitotic properties of resveratrol analog (Z)-3,5,4′-trimethoxystilbene

被引：29

作者：

Chabert, Philippe ^{[1
]}

Fougerousse, Andre ^{[1
]}

Brouillard, Raymond ^{[1
]}

机构：

[1] Univ Strasbourg 1, Fac Chim, CNRS, UMR 7177,Lab Chim Polyphenols, F-67000 Strasbourg, France

来源：

BIOFACTORS | 2006年 / 27卷 / 1-4期

关键词：

polyphenol; resveratrol; anti-mitotic; Caco-2; cells; colon cancer; tubulin;

D O I：

10.1002/biof.5520270104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Z)-3,5,4'-Trimethoxystilbene is a natural polyphenol present in five different plants, Virola cuspidata, Virola elongata, Centipeda minima, Schoenus nigricans and Rheum undulatum. This molecule was prepared in a three-step sequence in good overall yield. The isomerisation from the (E)- to (Z)-isomer is performed using UV irradiation. Biological investigations were conducted on a human colon cancer cell line (Caco-2) with anti-mitotic activities. Growth was completely arrested at an added 0.4 mu M level of (Z)-3,5,4'-trimethoxystilbene. This agent is 100-fold more active than resveratrol or (E)-3,5,4'trihydroxystilbene, and the mechanism of this process involves an inhibition of tubulin polymerisation in a dose dependent manner.

引用

页码：37 / 46

页数：10

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