Pathways to mitochondrial dysfunction in ALS pathogenesis

被引：76

作者：

Carri, Maria Teresa ^{[1
,2
]}

D'Ambrosi, Nadia ^{[3
]}

Cozzolino, Mauro ^{[4
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biol, Via Ric Sci, I-00133 Rome, Italy

[2] Fdn Santa Lucia, IRCCS, Via Fosso Fiorano 64, I-00143 Rome, Italy

[3] Univ Cattolica Sacro Cuore, Inst Anat & Cell Biol, Largo Francesco Vito 1, I-00168 Rome, Italy

[4] CNR, Inst Translat Pharmacol, Via Fosso Cavaliere 100, I-00133 Rome, Italy

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 483卷 / 04期

关键词：

Amyotrophic Lateral Sclerosis; Mitochondria; Protein aggregation; Mitophagy; Alternative splicing; AMYOTROPHIC-LATERAL-SCLEROSIS; PRION-LIKE PROPAGATION; MUTANT SOD1; FRONTOTEMPORAL DEMENTIA; CALCIUM HOMEOSTASIS; AUTOPHAGY RECEPTOR; AXONAL-TRANSPORT; C9ORF72; DYNAMICS; AGGREGATION;

D O I：

10.1016/j.bbrc.2016.07.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Alterations in the structure and functions of mitochondria are a typical trait of Amyotrophic Lateral Sclerosis, a neurodegenerative disease characterized by a prominent degeneration of upper and lower motor neurons. The known gene mutations that are responsible for a small fraction of ALS cases point to a complex interplay between different mechanisms in the disease pathogenesis. Here we will briefly overview the genetic and mechanistic evidence that make dysfunction of mitochondria a candidate major player in this process. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：1187 / 1193

页数：7

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