Ebselen effects on MPTP-induced neurotoxicity

被引：18

作者：

Dhanasekaran, Muralikrishnan ^{[1
]}

Uthayathas, Subramaniam

Karuppagounder, Senthilkumar S.

Parameshwaran, Kodeeswaran

Suppiramaniam, Vishnu

Ebadi, Manuchair

Brown-Borg, Holly M.

机构：

[1] Auburn Univ, Harrison Sch Pharm, Div Pharmacol & Toxicol, Dept Pharmacal Sci, Auburn, AL 36849 USA

[2] Univ N Dakota, Sch Med & Hlth Sci, Dept Pharmacol, Grand Forks, ND 58201 USA

来源：

BRAIN RESEARCH | 2006年 / 1118卷

关键词：

Ebselen; MPTP; monoamine oxidase; neuroprotection; SH-SY5Y cell;

D O I：

10.1016/j.brainres.2006.08.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 mu M) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum. (c) 2006 Elsevier B.V. All rights reserved.

引用

收藏

页码：251 / 254

页数：4

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