Estrone and 17β-estradiol reverse breast cancer resistance protein-mediated multidrug resistance

被引：75

作者：

Imai, Y

Tsukahara, S

Ishikawa, E

Tsuruo, T

Sugimoto, Y

机构：

[1] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Div Mol Biotherapy, Toshima Ku, Tokyo 1708455, Japan

[2] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Div Expt Chemotherapy, Toshima Ku, Tokyo 1708455, Japan

[3] Univ Tokyo, Inst Mol & Cellular Biol, Bunkyo Ku, Tokyo 1130032, Japan

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 2002年 / 93卷 / 03期

关键词：

BCRP; estrone; 17; beta-estradiol; MDR; reversal of drug resistance;

D O I：

10.1111/j.1349-7006.2002.tb02162.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer resistance protein (BCRP), an adenosine triphosphate-binding cassette transporter, confers resistance to a series of anticancer reagents, including mitoxantrone, SN-38 and topotecan. In the present study, we found that estrone and 17beta-estradiol potentiated the cytotoxicity of mitoxantrone, SN-38 and topotecan in BCRP-transduced K562 cells (K562/BCRP). These estrogens showed only a marginal effect, or none, in parental K562 cells. Estrone and 17beta-estradiol increased the cellular accumulation of topotecan in K562/BCRP cells, but not in K562 cells, suggesting that these estrogens inhibit the BCRP-mediated drug efflux and overcome drug resistance.

引用

页码：231 / 235

页数：5

共 16 条

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