Role of C-reactive protein in schizophrenia: An overview

被引:83
作者
Singh, Bisu [1 ,2 ]
Chaudhuri, Tapas Kumar [2 ]
机构
[1] Balurghat Coll, Dept Zool, Dakshin Dinajpur 733101, W Bengal, India
[2] Univ N Bengal, Dept Zool, Cellular Immunol Lab, Siliguri 734013, W Bengal, India
关键词
C-reactive protein; Inflammation; IL-6; Schizophrenia; NERVOUS-SYSTEM INFECTIONS; CRITICALLY-ILL PATIENTS; APPARENTLY HEALTHY-MEN; ACUTE-PHASE RESPONSE; 3RD NATIONAL-HEALTH; AMYLOID-P-COMPONENT; BIPOLAR DISORDER; SERUM-LEVELS; CRP GENE; PLASMA-CONCENTRATIONS;
D O I
10.1016/j.psychres.2014.02.004
中图分类号
R749 [精神病学];
学科分类号
100204 [神经病学];
摘要
Over the years, schizophrenia is speculated to be associated with immune or inflammatory reactions mediated by cytokines. It is proposed that chronic inflammation might damage the micro-vascular system of brain and hamper cerebral blood flow. Scientific evidence suggests that an increase of stress hormone like norepinephrine may activate the inflammatory arm of the immune system and trigger the expression of genes that cause chronic, low-grade inflammation. Thus, studies were conducted to decipher the potentiality of CRP as a marker for inflammation in schizophrenia. This article reviews the findings of CRP in schizophrenia, and the limitations of the previous studies have been discussed. The importance of simultaneous study of CRP modulating cytokines and CRP gene polymorphism in the study of serum or plasma level of CRP has been emphasized. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:277 / 285
页数:9
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