Involvement of FcRγ in signal transduction of osteoclast-associated receptor (OSCAR)

被引：42

作者：

Ishikawa, S

Arase, N

Suenaga, T

Saita, Y

Noda, M

Kuriyama, T

Arase, H ^{[1
]}

Saito, T

机构：

[1] Chiba Univ, Grad Sch Med, Dept Mol Genet, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Dept Respirol, Chiba, Japan

[3] RIKEN Res Ctr Allergy & Immunol, Lab Cell Signaling, Yokohama, Kanagawa, Japan

[4] Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Pharmacol, Tokyo, Japan

[5] Osaka Univ, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

[6] Japan Sci & Technol Agcy, PRESTO, Saitama, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 2004年 / 16卷 / 07期

基金：

日本科学技术振兴机构;

关键词：

CD3; zeta; Fc receptor; Ig-like receptor; ITAM; osteoclast;

D O I：

10.1093/intimm/dxh103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Osteoclasts regulate homeostasis of bone development. A defect in osteoclast development results in osteopetrosis. Recently, the involvement of several molecules in osteoclast development has been found. Osteoclast-associated receptor (OSCAR) is one of such molecules critical for osteoclast differentiation. However, it remains unclear how OSCAR transduces signals for osteoclast differentiation. Here, we found that the FcRgamma chain, a signal transducing adaptor molecule for Fc receptors, is associated with OSCAR and is involved in the cell surface expression of OSCAR. Furthermore, FcRgamma is required for signal transduction by OSCAR. These findings suggest that the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation.

引用

页码：1019 / 1025

页数：7

共 29 条

[1] DIFFERENT CYTOPLASMIC STRUCTURE OF THE CD3-ZETA FAMILY DIMER MODULATES THE ACTIVATION SIGNAL AND FUNCTION OF T-CELLS [J].