Formulation of a neutral solution of ciprofloxacin upon complexation with aluminum

被引：14

作者：

Allemandi, DA ^{[1
]}

Alovero, F ^{[1
]}

Manzo, RH ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farm, RA-5000 Cordoba, Argentina

来源：

FARMACO | 1999年 / 54卷 / 11-12期

关键词：

ciprofloxacin; solutions; complexation;

D O I：

10.1016/S0014-827X(99)00095-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Clear solutions of 0.5 and 1.0% ciprofloxacin (CF) of pH 7.2 were prepared by the addition of aluminum chloride hexahydrate (AlCl3 . 6H(2)O) in the molar proportion CF:AlCl3 . 6H(2)O (3:1). Minimum inhibitory concentrations (MIC) of these solutions were the same as an equimolar solution of CF . HCl. Solutions exhibited good physical, chemical and microbiological stability and satisfactorily overcame an ocular irritation test on rabbits. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：758 / 760

页数：3

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