Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma

被引：32

作者：

Jin, Shaoju ^{[1
,2
]}

Mu, Yishuang ^{[1
]}

Wang, Xiaodong ^{[3
]}

Liu, Zhenru ^{[1
]}

Wan, Lihong ^{[1
]}

Xiong, Yao ^{[1
]}

Zhang, Yuanyuan ^{[1
]}

Zhou, Liming ^{[1
,4
]}

Li, Li ^{[3
]}

机构：

[1] Sichuan Univ, West China Sch Preclin & Forens Med, Dept Pharmacol, Chengdu 610041, Peoples R China

[2] Ningxia Med Univ, Sch Pharm, Dept Pharmacol, Yinchuan 750004, Peoples R China

[3] Sichuan Univ, Dept Gastrointestinal Surg Ctr, West China Hosp, Chengdu 610041, Peoples R China

[4] Sichuan Univ, Chengdu 610041, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 05期

关键词：

RACK1; Colorectal carcinoma; Malignant degree; Positive correlation; PROTEIN-KINASE-C; INTRACELLULAR RECEPTOR; SRC ACTIVITY; CANCER; GROWTH;

D O I：

10.1007/s11033-014-3201-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

RACK1 is a crucial scaffold and anchoring protein, which plays a vital role in multiple signaling pathways of tumorigenesis. The aim of the present study was to identify the correlation between expressions of RACK1 and malignant degrees in colorectal carcinoma (CRC) patients. All together 157 CRC patients were enrolled, and their clinical data were analyzed. Expressions of RACK1 in CRC and pericarcinous tissues in these patients were determined by RT-PCR, Western-blot, and immunohistochemistry, respectively. The correlation between RACK1 expressions and histological grades, as well as lymph node metastasis was evaluated. Results showed that the expressions of RACK1 were positively correlated with differentiation level and lymph node metastasis in CRC patients.

引用

页码：3393 / 3399

页数：7

共 26 条

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