8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src kinase inhibitors

被引：16

作者：

Berger, D ^{[1
]}

Dutia, M

Powell, D

Wu, BQ

Wissner, A

DeMorin, F

Weber, J

Boschelli, F

机构：

[1] Wyeth Ayerst Res, Chem Sci, Pearl River, NY 10965 USA

[2] Wyeth Ayerst Res, Discovery Oncol, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(02)00524-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2761 / 2765

页数：5

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