Subtype selective tetracycline agonists and their application for a two-stage regulatory system

被引：25

作者：

Berens, Christian

Lochner, Susanne

Loeber, Stefan

Usai, Igor

Schmidt, Andreas

Drueppel, Lars

Hillen, Wolfgang

Gmeiner, Peter

机构：

[1] Univ Erlangen Nurnberg, Dept Med Chem, Emil Fischer Ctr, D-91052 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Microbiol, D-91058 Erlangen, Germany

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 09期

关键词：

antibiotics; chemical biology; doxycycline; gene expression; gene technology;

D O I：

10.1002/cbic.200600226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We are in control. Rational-based structural modifications of tetracycline derivatives that can act as selective inducers of the transactivating proteins rtTA-1/2 and rtTA-D have been carried out. These modifications led to a novel two-stage regulatory system in which two separate genes can be regulated by using the selective inducers 9-dipropylaminodoxycycline (1) and doxycycline (dox). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1320 / 1324

页数：5

共 40 条

[1]

[Anonymous], 2006, ANGEW CHEM, V118, P2287

[2]

[Anonymous], 2000, ANGEW CHEM, V112, P2122

[3] Palladium-catalyzed reaction of o-ethynylphenols, o-((trimethylsilyl)ethynyl)phenyl acetates, and o-alkynylphenols with unsaturated triflates or halides: A route to 2-substituted-, 2,3-disubstituted-, and 2-substituted-3-acylbenzo[b]furans [J].