Effects of portal-systemic shunt following 90% partial hepatectomy in rats

被引:33
作者
Fukuchi, T [1 ]
Hirose, H [1 ]
Onitsuka, A [1 ]
Hayashi, M [1 ]
Senga, S [1 ]
Imai, N [1 ]
Shibata, M [1 ]
Yamauchi, K [1 ]
Futamura, N [1 ]
Sumi, Y [1 ]
机构
[1] Gifu Univ, Sch Med, Dept Surg 1, Gifu 500, Japan
关键词
90% partial hepatectomy; portal-systemic shunt; splanchnic hemodynamics; dye microsphere;
D O I
10.1006/jsre.1999.5810
中图分类号
R61 [外科手术学];
学科分类号
摘要
We studied the effects of portal-systemic shunt after massive hepatectomy, Male Wistar rats were divided into two groups: one group underwent laparotomy alone (C group) and in the other group a portal-systemic shunt was placed through laparotomy (S group). After 90% hepatectomy was performed, 3-day and 1-week survival rates and histopathology were examined, and hepatic hemodynamics during the early stage after hepatectomy were measured using dye-containing microspheres. The 3-day survival rate in the S group was significantly higher, and the 1-week survival rate was slightly higher, than those in C group. Sinusoidal dilation 7 days after hepatectomy in the S group was significantly milder than that in the C group. Fatty degeneration of hepatocytes in the S group was significantly milder than that in the C group. With respect to hepatic hemodynamics during the early stage after hepatectomy, the rate of shunt (26.3%) in the S group was significantly higher than that (9.5%) in the C group. Portal pressure, total hepatic blood flow, and total hepatic blood flow per gram of liver in the S group were significantly lower than those in the C group. These results suggest that approximately 26% shunt after 90% hepatectomy in rats increases the early survival rate and improves histological changes in surviving rats 7 days after resection. (C) 2000 Academic Press.
引用
收藏
页码:126 / 131
页数:6
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