Modeling cognitive endophenotypes of schizophrenia in mice

被引：105

作者：

Kellendonk, Christoph ^{[1
,2
,3
]}

Simpson, Eleanor H. ^{[1
,3
]}

Kandel, Eric R. ^{[1
,3
,4
,5
]}

机构：

[1] Columbia Univ, Dept Psychiat, New York, NY 10032 USA

[2] Columbia Univ, Dept Pharmacol, New York, NY 10032 USA

[3] Columbia Univ, Lieber Ctr Schizophrenia Res, New York, NY 10032 USA

[4] Columbia Univ, Dept Neurosci, New York, NY 10032 USA

[5] Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

TRENDS IN NEUROSCIENCES | 2009年 / 32卷 / 06期

关键词：

CATECHOL-O-METHYLTRANSFERASE; 22Q11 DELETION SYNDROME; DOPAMINE D2 RECEPTOR; DIGEORGE-SYNDROME REGION; CARDIO-FACIAL SYNDROME; WORKING-MEMORY; PREFRONTAL CORTEX; D-2; RECEPTORS; BIPOLAR DISORDER; DISC1; DISRUPTED-IN-SCHIZOPHRENIA-1;

D O I：

10.1016/j.tins.2009.02.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenia is a complex mental disorder that is still characterized by its symptoms rather than by biological markers because we have only a limited knowledge of its underlying molecular basis. In the past two decades, however, technical advances in genetics and brain imaging have provided new insights into the biology of the disease. Based on these advances we are now in a position to develop animal models that can be used to test specific hypotheses of the disease and explore mechanisms of pathogenesis. Here, we consider some of the insights that have emerged from studying in mice the relationship between defined genetic and molecular alterations and the cognitive endophenotypes of schizophrenia.

引用

收藏

页码：347 / 358

页数：12

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