Diet and asthma: vitamins and methyl donors

被引：54

作者：

Han, Yueh-Ying ^{[1
]}

Blatter, Josh ^{[1
]}

Brehm, John M. ^{[1
]}

Forno, Erick ^{[1
]}

Litonjua, Augusto A. ^{[2
,3
]}

Celedon, Juan C. ^{[1
]}

机构：

[1] Univ Pittsburgh, Childrens Hosp Pittsburgh, UPMC, Div Pediat Pulm Med Allergy & Immunol,Dept Pediat, Pittsburgh, PA 15213 USA

[2] Harvard Univ, Sch Med, Dept Med, Channing Div Network Med,Brigham & Womens Hosp, Boston, MA USA

[3] Harvard Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med,Brigham & Womens Hosp, Boston, MA USA

来源：

LANCET RESPIRATORY MEDICINE | 2013年 / 1卷 / 10期

关键词：

25-HYDROXYVITAMIN D LEVELS; FOLIC-ACID SUPPLEMENTS; LUNG-FUNCTION; OXIDATIVE STRESS; EARLY-CHILDHOOD; PULMONARY-FUNCTION; ANTIOXIDANT INTAKE; RESPIRATORY-INFECTION; AIRWAY INFLAMMATION; FOLATE METABOLISM;

D O I：

10.1016/S2213-2600(13)70126-7

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Diet changes can partly explain the high burden of asthma in industrialised nations. Findings from experimental studies have stimulated many observational studies of the association between vitamins (A, C, D, and E) or nutrients acting as methyl donors (folate, vitamin B-12, and choline) and asthma. However, observational studies are susceptible to several sources of bias; well conducted randomised controlled trials (RCTs) are the gold standard to establish whether diet has an effect on asthma. Evidence from observational studies and a few RCTs strongly justifies ongoing and future RCTs in three areas: vitamin D for the prevention or treatment of asthma, choline supplementation as adjuvant treatment for asthma, and vitamin E to prevent the detrimental effects of air pollution in patients with asthma. At present, insufficient evidence exists to recommend supplementation with any vitamin or nutrient acting as a methyl donor to prevent or treat asthma.

引用

页码：813 / 822

页数：10

共 117 条

[1]

Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis [J].