Scavenger receptor BI - a cell surface receptor for high density lipoprotein

被引：181

作者：

Rigotti, A ^{[1
]}

Trigatti, B ^{[1
]}

Babitt, J ^{[1
]}

Penman, M ^{[1
]}

Xu, SH ^{[1
]}

Krieger, M ^{[1
]}

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

CURRENT OPINION IN LIPIDOLOGY | 1997年 / 8卷 / 03期

关键词：

D O I：

10.1097/00041433-199706000-00009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The receptor-mediated transfer of lipids between cells and lipoproteins plays an important role in lipoprotein metabolism and cardiovascular disease. Although there have been many valuable studies of HDL binding to tissues, cells and membranes, and of the potential role of such binding in the transport of lipids between HDL and cells, much less is known about HDL receptors than about receptors for other lipoproteins (e.g. LDL, chylomicrons, vitellogenin) Here we review recent studies of the class B, type I scavenger receptor, which appears to be a physiologically relevant, cell surface HDL receptor that mediates the selective uptake of lipids by cells.

引用

页码：181 / 188

页数：8

共 113 条

[1] Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].