Platelet activity: an obstacle for successful PCI

被引:16
作者
Gawaz, Meinrad [1 ]
Geisler, Tobias [1 ]
机构
[1] Univ Tubingen, Dept Cardiol, D-72074 Tubingen, Germany
关键词
ELUTING STENT THROMBOSIS; CLOPIDOGREL; REACTIVITY;
D O I
10.1038/nrcardio.2009.76
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dual antiplatelet therapy with aspirin and clopidogrel is effective in limiting adverse coronary thromboischemic events in most patients undergoing coronary stenting. However, platelet reactivity to clopidogrel is variable and stent thrombosis can occur suddenly and unexpectedly in up to 3% of patients. is responsiveness to clopidogrel an indicator of risk of post-treatment thromboischemic events?
引用
收藏
页码:391 / 392
页数:2
相关论文
共 10 条
[1]   Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis [J].
Buonamici, Piergiovanni ;
Marcucci, Rossella ;
Migliorini, Angela ;
Gensini, Gian Franco ;
Santini, Alberto ;
Paruccia, Rita ;
Moschi, Guia ;
Gori, Anna Maria ;
Abbate, Rosanna ;
Antoniucci, David .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (24) :2312-2317
[2]  
Geisler T, 2008, J THROMB HAEMOST, V6, P54
[3]   Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation [J].
Geisler, Tobias ;
Langer, Harald ;
Wydymus, Magdalena ;
Goehring, Katrin ;
Zuern, Christine ;
Bigalke, Boris ;
Stellos, Konstantinos ;
May, Andreas E. ;
Gawaz, Meinrad .
EUROPEAN HEART JOURNAL, 2006, 27 (20) :2420-2425
[4]   Clopidogrel effect on platelet REactivity in patients with stent thrombosis - Results of the CREST study [J].
Gurbel, PA ;
Bliden, KP ;
Samara, W ;
Yoho, JA ;
Hayes, K ;
Fissha, MZ ;
Tantry, US .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 46 (10) :1827-1832
[5]   ANTIPLATELET THERAPY Personalized medicine for clopidogrel resistance? [J].
Hulot, Jean-Sebastien ;
Fuster, Valentin .
NATURE REVIEWS CARDIOLOGY, 2009, 6 (05) :334-336
[6]   Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement [J].
Müller, I ;
Besta, F ;
Schulz, C ;
Massberg, S ;
Schönig, A ;
Gawaz, M .
THROMBOSIS AND HAEMOSTASIS, 2003, 89 (05) :783-787
[7]   Prospective evaluation of hemostatic predictors of subacute stent thrombosis after coronary Palmaz-Schatz stenting [J].
Neumann, FJ ;
Gawaz, M ;
Ott, I ;
May, A ;
Mossmer, G ;
Schomig, A .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 27 (01) :15-21
[8]   Platelet Reactivity After Clopidogrel Treatment Assessed With Point-of-Care Analysis and Early Drug-Eluting Stent Thrombosis [J].
Sibbing, Dirk ;
Braun, Siegmund ;
Morath, Tanja ;
Mehilli, Julinda ;
Vogt, Wolfgang ;
Schoemig, Albert ;
Kastrati, Adnan ;
von Beckerath, Nicolas .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (10) :849-856
[9]   Clopidogrel non responsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis [J].
Snoep, Jaapjan D. ;
Hovens, Marcel M. C. ;
Eikenboom, Jeroen C. J. ;
van der Bom, Johanna G. ;
Jukema, J. Wouter ;
Huisman, Menno V. .
AMERICAN HEART JOURNAL, 2007, 154 (02) :221-231
[10]   Sirolimus-eluting versus uncoated stents in acute myocardial infarction [J].
Spaulding, Christian ;
Henry, Patrick ;
Teiger, Emmanuel ;
Beatt, Kevin ;
Bramucci, Ezio ;
Carrie, Didier ;
Slama, Michel S. ;
Merkely, Bela ;
Erglis, Andrejs ;
Margheri, Massimo ;
Varenne, Olivier ;
Cebrian, Ana ;
Stoll, Hans-Peter ;
Snead, David B. ;
Bode, Christoph .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (11) :1093-1104