Inhibitor of κB kinase is required to activate a subset of interferon γ-stimulated genes

被引：54

作者：

Sizemore, N

Agarwal, A

Das, K

Lerner, N

Sulak, M

Rani, S

Ransohoff, R

Shultz, D

Stark, GR

机构：

[1] Cleveland Clin Fdn, Dept Mol Biol, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Dept Canc Biol, Cleveland, OH 44195 USA

[3] Cleveland Clin Fdn, Dept Neurosci, Cleveland, OH 44195 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 21期

关键词：

D O I：

10.1073/pnas.0401593101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

IkappaB kinase (IKK), discovered as the major activator of NF-kappaB, plays additional roles in signaling. By using mouse embryo fibroblasts (MEFs) lacking both the alpha and beta subunits of IKK, we find that these proteins are required for induction of a major subset of IFNgamma-stimulated genes and that this requirement is independent of NF-kappaB activation. Furthermore, there is no defect in IFNgamma-stimulated signal transducer and activator of transcription 1 (Stat1) activation or function in the IKKalpha/beta-null MEFs. Therefore, although activated Stat1 dinners are necessary for the activation of these genes in response to IFNgamma, they are not sufficient. These results reveal an important additional pathway for IFNgamma-stimulated gene expression in which an NF-kappaB-independent function of IKK is required.

引用

收藏

页码：7994 / 7998

页数：5

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