Candidate gene studies of human pain mechanisms - Methods for optimizing choice of polymorphisms and sample size

被引：83

作者：

Belfer, I

Wu, TX

Kingman, A

Krishnaraju, RK

Goldman, D

Max, MB

机构：

[1] NIDCR, Pain & Neurosensory Mechanisms Branch, Div Intramural Res, NIH,US Dept HHS, Bethesda, MD 20892 USA

[2] NIDCR, Biostat Core, Div Populat & Hlth Promot Sci, NIH,US Dept HHS, Bethesda, MD 20892 USA

[3] NIAAA, Neurogenet Lab, NIH,US Dept HHS, Bethesda, MD 20892 USA

来源：

ANESTHESIOLOGY | 2004年 / 100卷 / 06期

关键词：

D O I：

10.1097/00000542-200406000-00032

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

There have been few clinical genetic studies of pain processing. The authors propose methods for the design of such studies to optimize the chance of success, including a systematic process to prioritize candidate alleles, sample size considerations, and the use of principles gleaned from analgesic clinical trials to maximize study sensitivity. These principles may also be applied to designing initial candidate gene studies in other clinical conditions.

引用

收藏

页码：1562 / 1572

页数：11

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