Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides

被引：53

作者：

Wimmer, N

Marano, RJ

Kearns, PS

Rakoczy, EP

Toth, I

机构：

[1] Univ Queensland, Sch Pharm, St Lucia, Qld 4072, Australia

[2] Univ Western Australia, Ctr Ophthalmol & Visual Sci, Nedlands, WA 6009, Australia

[3] Univ Western Australia, Lions Eye Inst, Nedlands, WA 6009, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 18期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0960-894X(02)00511-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of novel polycationic lipophilic peptide core(s) was accomplished and these agents successfully transfected human retinal pigment epithelium cells with ODN1 upon complexation with the oligonucleotide. The level of transfection was indirectly measured by the decreased production of the protein hVEGF (human vascular endothelial growth factor) in comparison to the transfection agent cytofectin GSV(TM). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2635 / 2637

页数：3

共 21 条

[1] The delivery of antisense therapeutics [J].