Glutathione S-transferase: genetics and role in toxicology

被引：302

作者：

Strange, RC ^{[1
]}

Jones, PW ^{[1
]}

Fryer, AA ^{[1
]}

机构：

[1] Keele Univ, Postgrad Med Sch, Clin Biochem Res Grp, Stoke On Trent, Staffs, England

来源：

TOXICOLOGY LETTERS | 2000年 / 112卷

关键词：

glutathione S-transferase; polymorphism; clinical outcome; basal cell carcinoma; ovarian cancer;

D O I：

10.1016/S0378-4274(99)00230-1

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The glutathione S-transferases (GST) are a supergene family of dimeric, enzymes that catalyse the conjugation of glutathione (GSH) to a variety of electrophiles including arene oxides, unsaturated carbonyls, organic halides and other substrates. Their importance is suggested by the finding that GST enzymes are expressed in probably all life forms. In humans, polymorphism in GST genes has been associated with susceptibility to various diseases though some recent data indicate that these genotypes modify disease phenotype. Thus, GST genotypes alone and in combination have been linked with clinical outcome. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：357 / 363

页数：7

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