Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3

被引：89

作者：

Wesson, CA ^{[1
]}

Deringer, J ^{[1
]}

Liou, LE ^{[1
]}

Bayles, KW ^{[1
]}

Bohach, GA ^{[1
]}

Trumble, WR ^{[1
]}

机构：

[1] Univ Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 05期

关键词：

D O I：

10.1128/IAI.68.5.2998-3001.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1 beta by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.

引用

页码：2998 / 3001

页数：4

共 21 条

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