Diverse catalytic activities in the αβ-hydrolase family of enzymes:: activation of H2O, HCN, H2O2, and O2

被引：58

作者：

Bugg, TDH ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

BIOORGANIC CHEMISTRY | 2004年 / 32卷 / 05期

关键词：

enzyme mechanism; alpha beta-hydrolase; C-C hydrolase; haloperoxidase; hydroxynitrile lyase; dioxygenase;

D O I：

10.1016/j.bioorg.2004.05.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The article describes the observation of novel catalytic activities in the alphabeta-hydrolase superfamily apparently unrelated to ester hydrolysis and unexpected biochemical observations relating to the structure and function of the serine catalytic triad in these enzymes. One common feature of these novel activities is the activation of a small diatomic molecule, but via diverse chemistry. Possible mechanisms of catalysis are discussed. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：367 / 375

页数：9

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