Advancing Our Understanding of the Glucose System via Modeling: A Perspective

被引：27

作者：

Cobelli, Claudio ^{[1
]}

Dalla Man, Chiara ^{[1
]}

Pedersen, Morten Gram ^{[1
]}

Bertoldo, Alessandra ^{[1
]}

Toffolo, Gianna ^{[1
]}

机构：

[1] Univ Padua, Dept Informat Engn, I-35131 Padua, Italy

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2014年 / 61卷 / 05期

关键词：

Artificial pancreas; diabetes; glucose control; insulin action; insulin secretion; minimal models; simulation models; CLOSED-LOOP CONTROL; BETA-CELL SENSITIVITY; INSULIN DELIVERY RATE; MINIMAL MODEL; ARTIFICIAL PANCREAS; MATHEMATICAL-MODEL; QUANTITATIVE ESTIMATION; EXPERIMENTAL VALIDATION; GLOBAL IDENTIFIABILITY; CYTOPLASMIC CA2+;

D O I：

10.1109/TBME.2014.2310514

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The glucose story begins with Claude Bernard's discovery of glycogen and milieu interieur, continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's paradigm of dynamic body constituents. Tracers and compartmental models allowed moving to the first quantitative pictures of the system and stimulated important developments in terms of modeling methodology. Three classes of multiscale models, models to measure, models to simulate, and models to control the glucose system, are reviewed in their historical development with an eye to the future.

引用

页码：1577 / 1592

页数：16

共 154 条

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