New molecular medicine-based scar management strategies

被引：68

作者：

Arno, Anna I. ^{[1
,2
,3
,4
]}

Gauglitz, Gerd G. ^{[5
]}

Barret, Juan P. ^{[3
,4
]}

Jeschke, Marc G. ^{[1
,2
]}

机构：

[1] Univ Toronto, Ross Tilley Burn Ctr, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Sunnybrook Res Inst, Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[3] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Plast Surg, Barcelona, Spain

[4] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Burn Unit, Barcelona, Spain

[5] Univ Munich, Dept Dermatol & Allergol, Munich, Germany

来源：

BURNS | 2014年 / 40卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Scar; Keloid; TGF-beta; Endoglin; Ski; SnoN; Fussels; FAP-alpha/DPPIV; Rapamycin; Review; GROWTH-FACTOR-BETA; TGF-BETA; COLLAGEN-SYNTHESIS; HYPERTROPHIC SCARS; INTERFERON-GAMMA; DIFFERENTIAL EXPRESSION; FLAVONOID QUERCETIN; DERMAL FIBROBLASTS; ALPHA SUPPRESSES; THYMOSIN BETA(4);

D O I：

10.1016/j.burns.2013.11.010

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-beta) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-beta 4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines. (C) 2013 Elsevier Ltd and ISBI. All rights reserved.

引用

页码：539 / 551

页数：13

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