Inhibition of transforming growth factor-β signaling in human cancer:: Targeting a tumor suppressor network as a therapeutic strategy

被引：65

作者：

Biswas, Swati

Criswell, Tracy L.

Wang, Shizhen Emily

Arteaga, Carlos L.

机构：

[1] Vanderbilt Univ, Med Ctr, Sch Med,Dept Med,Breast Canc Res Program, Vanderbilt Ingram Comprehens Canc Ctr,Div Oncol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Canc Biol,Breast Canc Res Program, Vanderbilt Ingram Comprehens Canc Ctr, Nashville, TN 37232 USA

来源：

CLINICAL CANCER RESEARCH | 2006年 / 12卷 / 14期

关键词：

D O I：

10.1158/1078-0432.CCR-06-0952

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

[No abstract available]

引用

页码：4142 / 4146

页数：5

共 69 条

[1]

Inhibition of TGFβ signaling in cancer therapy [J].

Arteaga, CL .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (01) :30-37

[2]

Bandyopadhyay A, 2002, CANCER RES, V62, P4690

[3]

Add-on anti-TGF-β antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat [J].

Benigni, A ;

Zoja, C ;

Corna, D ;

Zatelli, C ;

Conti, S ;

Campana, M ;

Gagliardini, E ;

Rottoli, D ;

Zanchi, C ;

Abbate, M ;

Ledbetter, S ;

Remuzzi, G .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (07) :1816-1824

[4]

TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia [J].

Bhowmick, NA ;

Chytil, A ;

Plieth, D ;

Gorska, AE ;

Dumont, N ;

Shappell, S ;

Washington, MK ;

Neilson, EG ;

Moses, HL .

SCIENCE, 2004, 303 (5659) :848-851

[5]

Bogdahn U, 2004, P AN M AM SOC CLIN, V23, P110

[6]

SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7 [J].

Byfield, SD ;

Major, C ;

Laping, NJ ;

Roberts, AB .

MOLECULAR PHARMACOLOGY, 2004, 65 (03) :744-752

[7]

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis [J].

Conery, AR ;

Cao, YN ;

Thompson, EA ;

Townsend, CM ;

Ko, TC ;

Luo, KX .

NATURE CELL BIOLOGY, 2004, 6 (04) :366-372

[8]

TGF beta 1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice [J].

Cui, W ;

Fowlis, DJ ;

Bryson, S ;

Duffie, E ;

Ireland, H ;

Balmain, A ;

Akhurst, RJ .

CELL, 1996, 86 (04) :531-542

[9]

Smad-dependent and Smad-independent pathways in TGF-β family signalling [J].

Derynck, R ;

Zhang, YE .

NATURE, 2003, 425 (6958) :577-584

[10]

DICKSON MC, 1995, DEVELOPMENT, V121, P1845

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