Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

被引：71

作者：

An, Min Ji

Cheon, Jae Hee ^{[1
]}

Kim, Seung Won

Kim, Eun Soo

Kim, Tae Il

Kim, Won Ho

机构：

[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea

来源：

CANCER LETTERS | 2009年 / 279卷 / 01期

关键词：

Guggulsterone; Colorectal cancer; Apoptosis; Xenograft; FACTOR-KAPPA-B; PLANT COMMIPHORA-MUKUL; ACTIVATION; KINASE; BCL-2; CLEAVAGE; PATHWAY; CHOLESTEROL; CONSTITUENT; SUPPRESSION;

D O I：

10.1016/j.canlet.2009.01.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：93 / 100

页数：8

共 37 条

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