Fatal attraction: tumors beckon regulatory T cells

被引：91

作者：

Shevach, EM ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 09期

关键词：

D O I：

10.1038/nm0904-900

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumor tissue and ascites from patients with ovarian cancer contain high levels of cells with all the hallmarks of regulatory T cells. These cells migrate into the tumor microenvironment in a process mediated by the chemokine CCL22, and are capable of suppressing antitumor responses ( pages 942 - 949).

引用

收藏

页码：900 / 901

页数：3

相关论文

共 11 条

[1] Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival [J].

Curiel, TJ ;

Coukos, G ;

Zou, LH ;

Alvarez, X ;

Cheng, P ;

Mottram, P ;

Evdemon-Hogan, M ;

Conejo-Garcia, JR ;

Zhang, L ;

Burow, M ;

Zhu, Y ;

Wei, S ;

Kryczek, I ;

Daniel, B ;

Gordon, A ;

Myers, L ;

Lackner, A ;

Disis, ML ;

Knutson, KL ;

Chen, LP ;

Zou, WP .

NATURE MEDICINE, 2004, 10 (09) :942-949

[2]

Kreitman RJ, 2003, CURR OPIN MOL THER, V5, P44

[3] Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma [J].

Liyanage, UK ;

Moore, TT ;

Joo, HG ;

Tanaka, Y ;

Herrmann, V ;

Doherty, G ;

Drebin, JA ;

Strasberg, SM ;

Eberlein, TJ ;

Goedegebuure, PS ;

Linehan, DC .

JOURNAL OF IMMUNOLOGY, 2002, 169 (05) :2756-2761

[4] Foxp3 and natural regulatory T cells: Key to a cell lineage? [J].

Ramsdell, F .

IMMUNITY, 2003, 19 (02) :165-168

[5] Regulatory T cells in autoimmmunity [J].

Shevach, EM .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :423-449

[6]

Shimizu J, 1999, J IMMUNOL, V163, P5211

[7]

STEPHENS GL, IN PRESS J IMMUNOL

[8] Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses [J].

Sutmuller, RPM ;

van Duivenvoorde, LM ;

van Elsas, A ;

Schumacher, TNM ;

Wildenberg, ME ;

Allison, JP ;

Toes, REM ;

Offringa, R ;

Melief, CJM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (06) :823-832

[9] Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific [J].

Thornton, AM ;

Shevach, EM .

JOURNAL OF IMMUNOLOGY, 2000, 164 (01) :183-190

[10] Tumor-specific human CD4+ regulatory T cells and their ligands:: Implications for immunotherapy [J].

Wang, HY ;

Lee, DA ;

Peng, GY ;

Guo, Z ;

Li, YC ;

Kiniwa, Y ;

Shevach, EM ;

Wang, RF .

IMMUNITY, 2004, 20 (01) :107-118