5-HT1A autoreceptor antagonist-induced 5-HT release in the hamster suprachiasmatic nuclei:: effects on circadian clock resetting

被引：16

作者：

Antle, MC

Glass, JD

Mistlberger, RE ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Psychol, Burnaby, BC V5A 1S6, Canada

[2] Kent State Univ, Dept Biol Sci, Kent, OH 44242 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 282卷 / 1-2期

关键词：

circadian rhythms; serotonin; WAY100635; non-photic entrainment; microdialysis; wheel running;

D O I：

10.1016/S0304-3940(00)00873-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin (5-HT) has been implicated in phase shifting of mammalian circadian rhythms by non-photic stimuli. This study tests whether pharmacological induction of endogenous 5-HT release can shift circadian phase in the Syrian hamster, Systemic injections of the 5-HT1A antagonist WAY100635 during the mid-subjective day significantly increased 5-HT in dialysate from the hamster suprachiasmatic nucleus (SCN) circadian pacemaker by similar to 50% for 40-60 min. However, this was not associated with phase shifts or with potentiation of phase shifts induced by a 3 h bout of running. These results indicate that enhanced 5-HT release in the SCN or possibly other regions is not sufficient to induce phase shifts in the subjective day. (C) 2000 Elsevier Science Ireland Ltd. Ali rights reserved.

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页码：97 / 100

页数：4

相关论文

共 22 条

[1] NEUROPEPTIDE-Y - ROLE IN LIGHT DARK CYCLE ENTRAINMENT OF HAMSTER CIRCADIAN-RHYTHMS [J].

ALBERS, HE ;

FERRIS, CF .

NEUROSCIENCE LETTERS, 1984, 50 (1-3) :163-168

[2] Serotonin antagonists do not attenuate activity-induced phase shifts of circadian rhythms in the Syrian hamster [J].

Antle, MC ;

Marchant, EG ;

Niel, L ;

Mistlberger, RE .

BRAIN RESEARCH, 1998, 813 (01) :139-149

[3] Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY100635, has partial agonist properties [J].

Assie, MB ;

Koek, W .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 304 (1-3) :15-21

[4] NEUROPEPTIDE-Y AND BEHAVIORALLY INDUCED PHASE-SHIFTS [J].

BIELLO, SM ;

JANIK, D ;

MROSOVSKY, N .

NEUROSCIENCE, 1994, 62 (01) :273-279

[5] Persistence of nonphotic phase shifts in hamsters after serotonin depletion in the suprachiasmatic nucleus [J].

Bobrzynska, KJ ;

Vrang, N ;

Mrosovsky, N .

BRAIN RESEARCH, 1996, 741 (1-2) :205-214

[6] Phase shifting by novelty-induced running: activity dose-response curves at different circadian times [J].

Bobrzynska, KJ ;

Mrosovsky, N .

JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 1998, 182 (02) :251-258

[7] Roles of suprachiasmatic nuclei and intergeniculate leaflets in mediating the phase-shifting effects of a serotonergic agonist and their photic modulation during subjective day [J].

Challet, E ;

Scarbrough, K ;

Penev, PD ;

Turek, FW .

JOURNAL OF BIOLOGICAL RHYTHMS, 1998, 13 (05) :410-421

[8] In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus [J].

Dudley, TE ;

Dinardo, LA ;

Glass, JD .

JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (04) :1469-1477

[9]

Dudley TE, 1998, J NEUROSCI, V18, P5045

[10] SEROTONIN AND THE MAMMALIAN CIRCADIAN SYSTEM .2. PHASE-SHIFTING RAT BEHAVIORAL RHYTHMS WITH SEROTONERGIC AGONISTS [J].

EDGAR, DM ;

MILLER, JD ;

PROSSER, RA ;

DEAN, RR ;

DEMENT, WC .

JOURNAL OF BIOLOGICAL RHYTHMS, 1993, 8 (01) :17-31