5-HT1A autoreceptor antagonist-induced 5-HT release in the hamster suprachiasmatic nuclei:: effects on circadian clock resetting

被引:16
作者
Antle, MC
Glass, JD
Mistlberger, RE [1 ]
机构
[1] Simon Fraser Univ, Dept Psychol, Burnaby, BC V5A 1S6, Canada
[2] Kent State Univ, Dept Biol Sci, Kent, OH 44242 USA
关键词
circadian rhythms; serotonin; WAY100635; non-photic entrainment; microdialysis; wheel running;
D O I
10.1016/S0304-3940(00)00873-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Serotonin (5-HT) has been implicated in phase shifting of mammalian circadian rhythms by non-photic stimuli. This study tests whether pharmacological induction of endogenous 5-HT release can shift circadian phase in the Syrian hamster, Systemic injections of the 5-HT1A antagonist WAY100635 during the mid-subjective day significantly increased 5-HT in dialysate from the hamster suprachiasmatic nucleus (SCN) circadian pacemaker by similar to 50% for 40-60 min. However, this was not associated with phase shifts or with potentiation of phase shifts induced by a 3 h bout of running. These results indicate that enhanced 5-HT release in the SCN or possibly other regions is not sufficient to induce phase shifts in the subjective day. (C) 2000 Elsevier Science Ireland Ltd. Ali rights reserved.
引用
收藏
页码:97 / 100
页数:4
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