Microviridins D-F, serine protease inhibitors from the cyanobacterium Oscillatoria agardhii (NIES-204)

被引:73
作者
Shin, HJ [1 ]
Murakami, M [1 ]
Matsuda, H [1 ]
Yamaguchi, K [1 ]
机构
[1] UNIV TOKYO, GRAD SCH AGR & AGR LIFE SCI, MARINE BIOCHEM LAB, BUNKYO KU, TOKYO 113, JAPAN
关键词
D O I
10.1016/0040-4020(96)00377-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
New serine protease inhibitors, microviridins D, E and F, were isolated from the cyanobacterium Oscillatoria agardhii (NIES-204). Their structures were elucidated to be 1-3 by extensive 2D NMR data and chemical degradation. These dicyclic or cyclic peptides inhibited serine protease potently. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:8159 / 8168
页数:10
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