Expression and prognostic relevance of STAT3 and cyclin D1 in non-small cell lung cancer

被引:27
作者
Ai, Ting [1 ,2 ]
Wang, Zhouquan [3 ]
Zhang, Mingxin [4 ]
Zhang, Lingmin [5 ]
Wang, Ning
Li, Weiwei
Song, Liping [2 ]
机构
[1] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Neonatol, Xian 710061, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Radiat Oncol, Xian 710061, Shaanxi, Peoples R China
[3] Sengong Hosp, Dept Oncol, Sengong, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Thorac Surg, Xian 710061, Shaanxi, Peoples R China
[5] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol, Xian 710061, Shaanxi, Peoples R China
关键词
Non-small cell lung cancer; Signal transducer and activator of transcription 3; Cyclin D1; SIGNAL TRANSDUCER; MARKERS; TRANSCRIPTION-3; ACTIVATOR; EGFR;
D O I
10.5301/JBM.2012.9146
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
Aim: To guide clinicians in selecting treatment options for patients with non-small cell lung cancer (NSCLC), it is desirable to have reliable markers predicting clinical outcome. This study analyzed the correlation between signal transducer and activator of transcription 3 (STAT3) and cyclin D1 in NSCLC and their association with clinicopathological features and survival. Methods: We investigated 65 specimens of NSCLC tissues by immunohistochemistry using STAT3 and cyclin D1 antibodies. First we determined the correlation between STAT3 and cyclin D1 expression and the clinicopathological features of the tumor. Then we assessed the prognostic relevance of STAT3 and cyclin D1. Results: A significant correlation was found between high levels of STAT3 expression and the degree of tumor differentiation. Additionally, a significant positive correlation was found between the expression of STAT3 and cyclin D1 (r=0.405, p=0.001). The overexpression of STAT3 and the presence of metastasis were significantly associated with shorter overall survival in univariate analysis (p=0.028 and p=0.036, respectively). Multivariate analysis confirmed that STAT3 expression was an independent prognostic factor (p=0.001). Conclusions: STAT3 might be correlated with tumor differentiation, and its elevated expression may be an adverse prognostic indicator for patients with NSCLC. Activation of the STAT3/cyclin D1 signaling pathway may be attributed to the malignant transformation of NSCLC and may represent a possible target for therapy.
引用
收藏
页码:E132 / E138
页数:7
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