Comparative investigation of kinetic consequences associated with long-range electronic effects on catalytic ruthenium-promoted ring-closing metathesis

被引：22

作者：

Basu, K ^{[1
]}

Cabral, JA ^{[1
]}

Paquette, LA ^{[1
]}

机构：

[1] Ohio State Univ, Evans Lab Chem, Columbus, OH 43210 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 31期

关键词：

cyclization; metathesis; kinetics; ruthenium; electronic effects;

D O I：

10.1016/S0040-4039(02)01064-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

When exposed to the Grubbs ruthenium catalyst, trienyl substrates of type 4 undergo highly regioselective ring closure to give the common product 5. These reactions proceed invariably under pseudo-first-order kinetics, considerably faster when X = H (t(1/2) = 9.1), followed by X = CO2Et (t(1/2) = 26.5). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5453 / 5456

页数：4

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