Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli

被引：8

作者：

Mizushima, T ^{[1
]}

Matsuo, M ^{[1
]}

Sekimizu, K ^{[1
]}

机构：

[1] KYUSHU UNIV, FAC PHARMACEUT SCI, DEPT MICROBIOL, HIGASHI KU, FUKUOKA 81282, JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 01期

关键词：

D O I：

10.1128/AAC.41.1.193

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for the induction are similar to those required for DNA relaxation and much higher than those required for cell death.

引用

页码：193 / 195

页数：3

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