A single dose of interleukin-31 (IL-31) causes continuous itch-associated scratching behaviour in mice

被引：71

作者：

Arai, Iwao ^{[1
,2
]}

Tsuji, Minoru ^{[1
]}

Takeda, Hiroshi ^{[1
]}

Akiyama, Nobutake ^{[2
]}

Saito, Saburo ^{[2
]}

机构：

[1] Int Univ Hlth & Welf, Div Pharmacol, Sch Pharm, Ohtawara, Tochigi 3248510, Japan

[2] Jikei Univ, Dept Mol Immunol, Inst DNA Med, Tokyo, Japan

来源：

EXPERIMENTAL DERMATOLOGY | 2013年 / 22卷 / 10期

关键词：

IL-31; itch; pruritogen; scratch; serotonin; NC/NGA MICE; ATOPIC-DERMATITIS; T-CELLS; SKIN; INVOLVEMENT; INDUCTION; STRAINS;

D O I：

10.1111/exd.12222

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, over 1.5s) about 3h after administration followed by a gradual decrease for over 24h after administration. I.d. injection of IL-31 significantly increased the total LLS counts/24h but not short-lasting scratching (SLS, 0.3-1.5s). In skin-lesioned NC/Nga mice, the LLS but not SLS counts were significantly higher than those in non-skin-lesioned NC/Nga mice. We also investigated 5-HT-induced scratching in BALB/c mice, SLS but not LLS increased immediately after the injection and then decreased to baseline after at 20min. These results suggest that IL-31 may participate in the sensation of itching and promote scratching behaviour in skin-lesioned NC/Nga mice, an animal model of atopic dermatitis (AD).

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收藏

页码：669 / 671

页数：3

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