Drugs, leads, and drug-likeness: An analysis of some recently launched drugs

被引：193

作者：

Proudfoot, JR ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00244-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An analysis of the origins of recently launched drugs reveals that most were derived by modification of known drug structures or from lead structures obtained from the scientific literature. High-throughput screening did not have a significant impact on the derivation of these drugs. The drug structures are very closely related to their leads. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1647 / 1650

页数：4

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