Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease

被引:119
作者
Bondi, MW
Serody, AB
Chan, AS
Eberson-Shumate, SC
Delis, DC
Hansen, LA
Salmon, DP
机构
[1] Vet Affairs San Diego Healthcare Syst, Psychiat Serv 116B, La Jolla, CA 92161 USA
[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[3] Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China
[4] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[5] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
关键词
D O I
10.1037//0894-4105.16.3.335
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
The Stroop Color-Word Test (SCWT; C. Golden, 1978) was examined in 59 patients with probable Alzheimer's disease (AD) and in 51 demographically comparable normal control (NC) participants. AD patients produced significantly larger Stroop interference effects than NC participants, and level of dementia severity significantly influenced SCWT performance. Principal-components analyses demonstrated a dissociation in the factor structure of the Stroop trials between NC participants and AD patients, suggesting that disruption of semantic knowledge and speeded verbal processing in AD may be a major contributor to impairment on the incongruent trial. Results of clinicopathologic correlations in an autopsy-confirmed AD subgroup further suggest the invocation of a broad network of integrated cortical regions and executive and language processes underlying successful SCWT performance.
引用
收藏
页码:335 / 343
页数:9
相关论文
共 33 条
[1]   Cognitive and neurobiologic markers of early Alzheimer disease [J].
Albert, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13547-13551
[2]   Preclinical prediction of AD using neuropsychological tests [J].
Albert, MS ;
Moss, MB ;
Tanzi, R ;
Jones, K .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2001, 7 (05) :631-639
[3]  
[Anonymous], 1964, PSYCHOL AGING
[4]   INVESTIGATIONS OF THE FUNCTIONAL-ANATOMY OF ATTENTION USING THE STROOP TEST [J].
BENCH, CJ ;
FRITH, CD ;
GRASBY, PM ;
FRISTON, KJ ;
PAULESU, E ;
FRACKOWIAK, RSJ ;
DOLAN, RJ .
NEUROPSYCHOLOGIA, 1993, 31 (09) :907-922
[5]   Executive dysfunction in early Alzheimer's disease [J].
Binetti, G ;
Magni, E ;
Padovani, A ;
Cappa, SF ;
Bianchetti, A ;
Trabucchi, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 60 (01) :91-93
[6]  
Bondi Mark W, 1993, Clin Neuropsychol, V7, P161, DOI 10.1080/13854049308401518
[7]   Neuropsychological function and Apolipoprotein E genotype in the preclinical detection of Alzheimer's disease [J].
Bondi, MW ;
Salmon, DP ;
Galasko, D ;
Thomas, RG ;
Thal, LJ .
PSYCHOLOGY AND AGING, 1999, 14 (02) :295-303
[8]   Factor analysis of four measures of prefrontal lobe functioning [J].
Boone, KB ;
Ponton, MO ;
Gorsuch, RL ;
Gonzalez, JJ ;
Miller, BL .
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 1998, 13 (07) :585-595
[9]   Brain activation and pupil response during covert performance of the Stroop Color Word task [J].
Brown, GG ;
Kindermann, SS ;
Siegle, GJ ;
Granholm, E ;
Wong, EC ;
Buxton, RB .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 1999, 5 (04) :308-319
[10]   VISUAL-ATTENTION AND PERCEPTION IN PATIENTS WITH HUNTINGTONS-DISEASE - COMPARISONS WITH OTHER SUBCORTICAL AND CORTICAL DEMENTIAS [J].
FILOTEO, JV ;
DELIS, DC ;
ROMAN, MJ ;
DEMADURA, T ;
FORD, E ;
BUTTERS, N ;
SALMON, DP ;
PAULSEN, J ;
SHULTS, CW ;
SWENSON, M ;
SWERDLOW, N .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1995, 17 (05) :654-667