Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effectsu

被引：46

作者：

Xiao, Peng

Shen, Hui

Guo, Yan-Fang

Xiong, Dong-Hai

Liu, Yao-Zhong

Liu, Yong-Jun

Zhao, Lan-Juan

Long, Ji-Rong

Guo, Yan

Recker, Robert R.

Deng, Hong-Wen

机构：

[1] Univ Missouri, Sch Med, Dept Orthoped Surg, Kansas City, MO 64108 USA

[2] Univ Missouri, Sch Med, Dept Basic Med Sci, Kansas City, MO 64108 USA

[3] Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA

[4] Creighton Univ, Sch Med, Osteoporosis Res Ctr, Omaha, NE 68178 USA

[5] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ, Xian 710049, Shanxi, Peoples R China

[6] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Mol Genet, Xian 710049, Shanxi, Peoples R China

[7] Hunan Normal Univ, Coll Life Sci, Lab Mol & Stat Genet, Changsha, Hunan, Peoples R China

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

BMD; whole genome linkage; quantitative trait loci; epistatic interaction; gender-specific;

D O I：

10.1359/JBMR.060717

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

A genome-wide linkage scan was conducted using a large white sample to identify QTLs for BMD. We found QTLs in the total sample and the gender-specific subgroups, as well as significant epistatic interactions underlying BMD variations.

引用

页码：1536 / 1544

页数：9

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