Switch peptides in statu nascendi:: Induction of conformational transitions relevant to degenerative diseases

被引：149

作者：

Mutter, M ^{[1
]}

Chandravarkar, A ^{[1
]}

Boyat, C ^{[1
]}

Lopez, J ^{[1
]}

Dos Santos, S ^{[1
]}

Mandal, B ^{[1
]}

Mimna, R ^{[1
]}

Murat, K ^{[1
]}

Patiny, L ^{[1
]}

Saucède, L ^{[1
]}

Tuchscherer, G ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, EPFL BCH, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 32期

关键词：

Alzheimer's disease; circular dichroism; protein folding; protein structures; switch peptides;

D O I：

10.1002/anie.200454045

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.

引用

页码：4172 / 4178

页数：7

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