The number of CD34+ cells mobilized into the peripheral blood can predict the quality of subsequent collections

PBPC were mobilized using a variety of chemotherapy regimens plus G-CSF in a group of 126 consecutive patients. Data are presented that show a close correlation between the number of CD34(+) cells mobilized into the peripheral blood (PB) and the number of CD34(+) cells subsequently collected by leukapheresis (R = 0.904), On the basis of this correlation, a regression formula was calculated that could give an estimate of the total number of CD34(+) cells likely to be collected by leukapheresis from a given number of CD34(+) cells per microliter PB, An easy-to-read table has been compiled to show how this type of analysis can be applied to predict the likely dose of CD34(+) cells that will be obtained by leukapheresis over a wide range of patient weights.