The Impact of Kidney Development on the Life Course: A Consensus Document for Action The Low Birth Weight and Nephron Number Working Group

被引：125

作者：

Brenner, Barry M. ^{[2
,3
]}

Charlton, Jennifer ^{[4
]}

Luyckx, Valerie ^{[5
]}

Manfellotto, Dario ^{[6
]}

Perico, Norberto ^{[7
]}

Remuzzi, Giuseppe ^{[1
,7
,8
,9
]}

Somaschini, Marco ^{[10
]}

Valensise, Herbert ^{[11
]}

Adu, Dwomoa ^{[12
]}

Allegaert, Karel ^{[13
,14
,15
]}

Benedetto, Chiara ^{[16
]}

Cetin, Irene ^{[17
,18
]}

Chevalier, Robert ^{[19
]}

Cortinovis, Monica ^{[7
]}

D'Anna, Rosario ^{[20
]}

Duvekot, Johannes ^{[21
]}

Escribano, Joaquin ^{[22
]}

Fanos, Vassilios ^{[23
]}

Ferrazzi, Enrico ^{[24
]}

Frusca, Tiziana ^{[25
]}

Glassock, Richard J. ^{[26
]}

Gyselaers, Wilfried ^{[27
,28
]}

Mecacci, Federico ^{[29
]}

Montini, Giovanni ^{[30
]}

Osmond, Clive ^{[31
]}

Ramenghi, Luca ^{[32
]}

Romagnani, Paola ^{[33
,34
,35
]}

Santoro, Antonio ^{[36
]}

Simeoni, Umberto ^{[37
]}

Steegers, Eric A. P. ^{[38
]}

Vikse, Bjorn Egil ^{[39
,40
]}

机构：

[1] IRCCS Ist Ric Farmacol Mario Negri, Ctr Anna Maria Astori, Sci & Techno Pk Kilometro Rosso Via Stezzano 87, Bergamo, Italy

[2] Harvard Med Sch, Boston, MA USA

[3] Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

[4] Univ Virginia, Childrens Hosp, Dept Pediat, Div Nephrol, Charlottesville, VA USA

[5] Univ Zurich, Inst Biomed Eth, Zurich, Switzerland

[6] San Giovanni Calibita Fatebenefratelli Hosp, Fatebenefratelli Fdn, Dept Internal Med, AFaR Div, Rome, Italy

[7] IRCCS Ist Ric Farmacol Mario Negri, Clin Res Ctr Rare Dis Aldo & Cele Dacca, Bergamo, Italy

[8] Azienda Socio Sanitaria Terr ASST Papa Giovanni X, Unit Nephrol Dialysis & Transplantat, Bergamo, Italy

[9] Univ Milan, Hosp L Sacco, Dept Biomed & Clin Sci, Milan, Italy

[10] St Anna Clin, Unit Neonatol, Lugano, Switzerland

[11] Tor Vergata Univ, Dept Obstet & Gynecol, Rome, Italy

[12] Univ Ghana, Sch Med & Dent, Accra, Ghana

[13] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Pediat Surg, Rotterdam, Netherlands

[14] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Intens Care, Rotterdam, Netherlands

[15] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium

[16] Univ Turin, Dept Surg Sci, Unit Gynecol & Obstet, Turin, Italy

[17] Hosp L Sacco, Dept Biomed & Clin Sci, Unit Obstet & Gynecol, Milan, Italy

[18] Univ Milan, Ctr Fetal Res Giorgio Pardi, Milan, Italy

[19] Univ Virginia, Charlottesville, VA USA

[20] Univ Messina, Dept Human Pathol Adulthood & Childhood G Barresi, Unit Gynecol & Obstet, Messina, Italy

[21] Erasmus MC, Dept Obstet & Gynecol, Div Obstet & Prenatal Med, Rotterdam, Netherlands

[22] Univ Rovira & Virgili, IISPV, Pediat Res Unit, Reus, Spain

[23] Univ Cagliari, Azienda Osped Univ, Neonatal Intens Care Unit, Puericulture Inst & Neonatal Sect, Cagliari, Italy

[24] Univ Milan, ICP Buzzi Childrens Hosp, Sch Med, Dept Obstet Gynecol & Neonatol,Biomed & Clin Sci, Milan, Italy

[25] Univ Parma, Maggiore Hosp, Dept Obstet & Gynecol, Parma, Italy

[26] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Laguna Niguel, CA USA

[27] Hasselt Univ, Fac Med & Life Sci, Dept Physiol, Mobile Hlth Unit, Hasselt, Belgium

[28] Ziekenhuis Oost Limburg, Dept Gynecol, Genk, Belgium

[29] Univ Florence, Careggi Univ Hosp, Dept Biomed Expt & Clin Sci, Div Obstet & Gynecol, Florence, Italy

[30] Univ Milan, Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dept Clin Sci & Community Hlth,Pediat Nephrol & D, Milan, Italy

[31] Univ Southampton, Southampton Gen Hosp, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[32] Ist Giannina Gaslini, Neonatal Intens Care Unit, Genoa, Italy

[33] Univ Florence, Excellence Ctr Res Transfer & High Educ Dev Novo, Florence, Italy

[34] Univ Florence, Dept Biomed Exp & Clin Sci, Florence, Italy

[35] Meyer Childrens Univ Hosp, Nephrol Unit, Florence, Italy

[36] St Orsola Marcello Malpighi Hosp, Dept Nephrol & Dialysis, Bologna, Italy

[37] Univ Lausanne, Serv Pediat, Lausanne, Switzerland

[38] Erasmus Univ, Med Ctr Rotterdam, Dept Obstet & Gynecol, Div Obstet & Prenatal Med, Rotterdam, Netherlands

[39] Haugesund Hosp, Dept Med, Haugesund, Norway

[40] Univ Bergen, Dept Clin Med, Bergen, Norway

来源：

NEPHRON | 2017年 / 136卷 / 01期

关键词：

Low birth weight; Nephron number; Intrauterine growth restriction; Small for gestational age; Preterm birth; Programmed risk of hypertension; Programmed risk of kidney disease; Maternal nutrition; Infant and child nutrition; Neonatal acute kidney injury; FOR-GESTATIONAL-AGE; INTRAUTERINE GROWTH-RETARDATION; STAGE RENAL-DISEASE; MIDDLE-INCOME COUNTRIES; LONG-TERM RISK; SYSTOLIC BLOOD-PRESSURE; YOUNG-ADULT AGE; MATERNAL CALCIUM SUPPLEMENTATION; UNILATERAL URETERAL OBSTRUCTION; IMPAIRED GLUCOSE-TOLERANCE;

D O I：

10.1159/000457967

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world. (C) 2017 The Author(s) Published by S. Karger AG, Basel

引用

页码：3 / 49

页数：47

共 446 条

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