Selective cytotoxicity of ginkgetin from Selaginella moellendorffii

被引：93

作者：

Sun, CM

Syu, MJ

Huang, YT

Chen, CC

Ou, JC

机构：

[1] NATL YANG MING UNIV,INST MICROBIOL & IMMUNOL,TAIPEI 112,TAIWAN

[2] NATL YANG MING UNIV,INST TRADIT MED,TAIPEI 112,TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 04期

关键词：

D O I：

10.1021/np960608e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-directed fractionation of an ethanolic extract of Selaginella moellendorffii has led to the isolation of a known biflavone, ginkgetin (1). A dose-dependent inhibition was observed with 1 on the growth of OVCAR-3 (human ovarian adenocarcinoma) cells with 50% inhibition occurring at 1.8 mu g/mL. Nonbioactive fractions yielded four additional known biflavones, amentoflavone 7,4',7'',4'''-tetramethyl ether, kayaflavone, podocarpusflavone A, and amentoflavone.

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页码：382 / 384

页数：3

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