The structure, regulation, and function of ZAP-70

被引：166

作者：

Au-Yeung, Byron B. ^{[1
]}

Deindl, Sebastian ^{[2
,3
]}

Hsu, Lih-Yun ^{[1
]}

Palacios, Emil H. ^{[4
]}

Levin, Susan E. ^{[5
]}

Kuriyan, John ^{[2
,3
,6
]}

Weiss, Arthur ^{[1
]}

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, Rosalind Russell Med Res Ctr Arthrit, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Chem, Berkeley, CA 94720 USA

[4] Univ Calif San Francisco, Calif Inst Quantitat Biomed Res, Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94143 USA

[5] Williams Coll, Dept Biol, Williamstown, MA 01267 USA

[6] Univ Calif Berkeley, Lawrence Berkeley Lab, Phys Biosci Div, Berkeley, CA 94720 USA

来源：

IMMUNOLOGICAL REVIEWS | 2009年 / 228卷

关键词：

ZAP-70; signal transduction; T-cell receptor; pre-TCR signals; autoinhibition; ITAM; T-CELL-RECEPTOR; CHRONIC LYMPHOCYTIC-LEUKEMIA; PROTEIN-TYROSINE KINASE; SEVERE COMBINED IMMUNODEFICIENCY; OF-FUNCTION MUTATION; ANTIGEN RECEPTOR; CRYSTAL-STRUCTURE; THYMOCYTE DEVELOPMENT; AUTOIMMUNE ARTHRITIS; INTERDOMAIN B;

D O I：

10.1111/j.1600-065X.2008.00753.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The tyrosine ZAP-70 (zeta-associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal transduction pathways in T cells following T-cell receptor (TCR) engagement. The importance of ZAP-70 is evidenced by the severe combined immunodeficiency that occurs in ZAP-70-deficient mice and humans. In this review, we describe recent analyses of the ZAP-70 crystal structure, revealing a complex regulatory mechanism of ZAP-70 activity, the differential requirements for ZAP-70 and spleen tyrosine kinase (SyK) in early T-cell development, as well as the role of ZAP-70 in chronic lymphocytic leukemia and autoimmunity. Thus, the critical importance of ZAP-70 in TCR signaling and its predominantly T-cell-restricted expression pattern make ZAP-70 an attractive drug target for the inhibition of pathological T-cell responses in disease.

引用

页码：41 / 57

页数：17

共 76 条

[1]

B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia [J].

Allsup, DJ ;

Kamiguti, AS ;

Lin, K ;

Sherrington, PD ;

Matrai, Z ;

Slupsky, JR ;

Cawley, JC ;

Zuzel, N .

CANCER RESEARCH, 2005, 65 (16) :7328-7337

[2]

DEFECTIVE T-CELL RECEPTOR SIGNALING AND CD8(+) THYMIC SELECTION IN HUMANS LACKING ZAP-70 KINASE [J].

ARPAIA, E ;

SHAHAR, M ;

DADI, H ;

COHEN, A ;

ROIFMAN, CM .

CELL, 1994, 76 (05) :947-958

[3]

ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4+8+ thymocytes with limiting p56lck [J].

Ashe, JM ;

Wiest, DL ;

Abe, R ;

Singer, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1163-1167

[4]

Intramolecular regulatory switch in ZAP-70: Analogy with receptor tyrosine kinases [J].

Brdicka, T ;

Kadlecek, TA ;

Roose, JP ;

Pastuszak, AW ;

Weiss, A .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (12) :4924-4933

[5]

ANALYSIS OF THE INTERACTION OF ZAP-70 AND SYK PROTEIN-TYROSINE KINASES WITH THE T-CELL ANTIGEN RECEPTOR BY PLASMON RESONANCE [J].

BU, JY ;

SHAW, AS ;

CHAN, AC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :5106-5110

[6]

ZAP-70 DEFICIENCY IN AN AUTOSOMAL RECESSIVE FORM OF SEVERE COMBINED IMMUNODEFICIENCY [J].

CHAN, AC ;

KADLECEK, TA ;

ELDER, ME ;

FILIPOVICH, AH ;

KUO, WL ;

IWASHIMA, M ;

PARSLOW, TG ;

WEISS, A .

SCIENCE, 1994, 264 (5165) :1599-1601

[7]

ACTIVATION OF ZAP-70 KINASE-ACTIVITY BY PHOSPHORYLATION OF TYROSINE-493 IS REQUIRED FOR LYMPHOCYTE ANTIGEN RECEPTOR FUNCTION [J].

CHAN, AC ;

DALTON, M ;

JOHNSON, R ;

KONG, GH ;

WANG, T ;

THOMA, R ;

KUROSAKI, T .

EMBO JOURNAL, 1995, 14 (11) :2499-2508

[8]

A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases [J].

Chen, Huaibin ;

Ma, Jinghong ;

Li, Wanqing ;

Eliseenkova, Anna V. ;

Xu, Chongfeng ;

Neubert, Thomas A. ;

Miller, W. Todd ;

Mohammadi, Moosa .

MOLECULAR CELL, 2007, 27 (05) :717-730

[9]

ZAP-70 directly enhances TgM signaling in chronic lymphocytic leukemia [J].

Chen, LG ;

Apgar, J ;

Huynh, L ;

Dicker, F ;

Giago-McGahan, T ;

Rassenti, L ;

Weiss, A ;

Kipps, TJ .

BLOOD, 2005, 105 (05) :2036-2041

[10]

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia [J].

Chen, LG ;

Widhopf, G ;

Huynh, L ;

Rassenti, L ;

Rai, KR ;

Weiss, A ;

Kipps, TJ .

BLOOD, 2002, 100 (13) :4609-4614

← 1 2 3 4 5 6 7 8 →