Botulinum toxin A in hamstring spasticity

被引:72
作者
Corry, IS [1 ]
Cosgrove, AP
Duffy, CM
Taylor, TC
Graham, HK
机构
[1] Royal Belfast Hosp Sick Children, Dept Orthopaed Surg, Belfast BT9 7JB, Antrim, North Ireland
[2] Queens Univ Belfast, Musgrave Pk Hosp, Belfast BT9 7JB, Antrim, North Ireland
[3] Royal Childrens Hosp, Dept Orthopaed Surg, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
botulinum toxin; cerebral palsy; hamstrings; spasticity; gait;
D O I
10.1016/S0966-6362(99)00037-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hamstring injection of Botulinum toxin A (BtA) may have a role in the conservative management of flexed knee gait in cerebral palsy or in simulating the effect of surgery. Tell children who were likely to require future hamstring lengthening were injected. Short term outcome was assessed by clinical examination and 3-D gait analysis. Mean popliteal angle decreased by 16 degrees and maximum knee extension in stance increased by 8 degrees, the latter relapsing by 12 weeks. Mean pelvic tilt tended to increase suggesting that isolated hamstring weakening be approached with caution. Energy cost of walking was not significantly changed in six of the ten patients. A small increase in knee extension in stance was often associated with patient satisfaction. There are theoretical grounds for expecting an associated increased longitudinal muscle growth after BtA injection. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:206 / 210
页数:5
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