Tandem UPS: Sequential mono- and dialkylation of resin-bound glycine via automated synthesis

被引：25

作者：

Griffith, DL

ODonnell, MJ

Pottorf, RS

Scott, WL

Porco, JA

机构：

[1] ARGONAUT TECHNOL,SAN CARLOS,CA 94070

[2] INDIANA UNIV PURDUE UNIV,DEPT CHEM,INDIANAPOLIS,IN 46202

[3] ELI LILLY & CO,LILLY RES LABS,RES TECHNOL,INDIANAPOLIS,IN 46285

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(97)10484-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method has been developed for the synthesis of racemic alpha,alpha-disubstituted amino acids by a tandem alkylation process (''Tandem UPS'') on solid-support. Consecutive alkylations of Wang resin-bound benzophenone imines of glycine afforded unnatural, disubstituted amino acid derivatives. Automated chemical synthesis was used to efficiently optimize conditions for both formation and hydrolysis of resin-bound disubstituted benzophenone imines and to generate a matrix of disubstituted amino acid derivatives. (C) 1997 Elsevier Science Ltd.

引用

页码：8821 / 8824

页数：4

共 16 条

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