Nerve growth factor promoter driven neurotrophin-3 overexpression in the mouse and the protective effect of transgene on age-related behavioral deficits

被引：9

作者：

Kaisho, Y

Ohta, H

Miyamoto, M

Igarashi, K

机构：

[1] Takeda Chem Ind Ltd, Div Discovery Res, Discovery Res Labs 3, Osaka 5328686, Japan

[2] Takeda Chem Ind Ltd, Pharmaceut Res Div, Pharmacol Res Labs 1, Osaka 5328686, Japan

[3] Takeda Chem Ind Ltd, Div Discovery Res, Discovery Res Labs 2, Tsukuba, Ibaraki 3004247, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 277卷 / 03期

关键词：

neurotrophin-3; nerve growth factor; transgenic mouse; Morris water maze; EIA; brain;

D O I：

10.1016/S0304-3940(99)00874-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To clarify the biological function of neurotrophin-3 (NT-3) at the postnatal stage, we created a line of transgenic mice overexpressing NT-3 under the control of the mouse nerve growth factor gene promoter, Transgenic mice showed high-level NT-3 expression in the hippocampus and several tissues. We performed behavioral tests in young-adult (7-month-sold) and aged (25-months-old) mice. Although aged non-transgenic mice exhibited spatial learning impairments in the Morris water maze, overexpression of NT-3 protected against these age-dependent spatial learning impairments in mice. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：181 / 184

页数：4

共 14 条

[1] Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation [J].