Tiagabine-related non-convulsive status epilepticus in partial epilepsy:: three case reports and a review of the literature

被引：35

作者：

Kellinghaus, C ^{[1
]}

Dziewas, R ^{[1
]}

Lüdemann, P ^{[1
]}

机构：

[1] Univ Munster, Neurol Klin, Dept Neurol, D-48129 Munster, Germany

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2002年 / 11卷 / 04期

关键词：

tiagabine; partial epilepsy; non-convulsive status epilepticus; GABA receptor; review;

D O I：

10.1053/seiz.2001.0594

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There have been several recent reports of non-convulsive status epilepticus during tiagabine therapy in patients with partial epilepsy. We report three cases where elevation of tiagabine dosage was followed by electroclinical features, or electroencephalographic features without clinical signs, of non-convulsive status epilepticus. Administration of clonazepant and/or discontinuation to tiagabine lead to complete remission. In one case after re-exhibition of tiagabine the EEG again showed rhythmic delta waves. We review the other cases reported so far and discuss the different pathophysiological hypotheses about the association in the light of new experimental data. (C) 2002 BEA Trading Ltd. Published by Elsevier Science Ltd. All tights reserved

引用

页码：243 / 249

页数：7

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