Nuclear stress bodies: a heterochromatin affair?

被引：68

作者：

Biamonti, G ^{[1
]}

机构：

[1] CNR, Ist Genet Mol, I-27100 Pavia, Italy

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/nrm1405

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is still largely unknown how the various nuclear subcompartments are formed, why they form in particular locations and how they are linked to nuclear function. Nuclear stress bodies provide a new opportunity to address these questions and to test models of self-organization of nuclear structures. The assembly of these bodies requires the synthesis of non-coding RNAs with a probable role in the post-transcriptional regulation of gene expression and in higher-order chromatin organization.

引用

收藏

页码：493 / 498

页数：6

相关论文

共 40 条

[1] Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70 [J].

Alastalo, TP ;

Hellesuo, M ;

Sandqvist, A ;

Hietakangas, V ;

Kallio, M ;

Sistonen, L .

JOURNAL OF CELL SCIENCE, 2003, 116 (17) :3557-3570

[2] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[3] Alternative splicing:: multiple control mechanisms and involvement in human disease [J].

Cáceres, JF ;

Kornblihtt, AR .

TRENDS IN GENETICS, 2002, 18 (04) :186-193

[4]

Chiodi I, 2000, J CELL SCI, V113, P4043

[5]

Cotto JJ, 1997, J CELL SCI, V110, P2925

[6] Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies [J].

Denegri, M ;

Moralli, D ;

Rocchi, M ;

Biggiogera, M ;

Raimondi, E ;

Cobianchi, F ;

De Carli, L ;

Riva, S ;

Biamonti, G .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (06) :2069-2079

[7] Stress-induced nuclear bodies are sites of accumulation of pre-mRNA processing factors [J].

Denegri, M ;

Chiodi, I ;

Corioni, M ;

Cobianchi, F ;

Riva, S ;

Biamonti, G .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (11) :3502-3514

[8] INDUCTION OF B2 RNA POLYMERASE-III TRANSCRIPTION BY HEAT-SHOCK - ENRICHMENT FOR HEAT-SHOCK INDUCED SEQUENCES IN RODENT CELLS BY HYBRIDIZATION SUBTRACTION [J].

FORNACE, AJ ;

MITCHELL, JB .

NUCLEIC ACIDS RESEARCH, 1986, 14 (14) :5793-5811

[9] Establishment and maintenance of a heterochromatin domain [J].

Hall, IM ;

Shankaranarayana, GD ;

Noma, KI ;

Ayoub, N ;

Cohen, A ;

Grewal, SIS .

SCIENCE, 2002, 297 (5590) :2232-2237

[10] Glycogen synthase kinase 3β and extracellular signal-regulated kinase inactivate heat shock transcription factor 1 by facilitating the disappearance of transcriptionally active granules after heat shock [J].

He, B ;

Meng, YH ;

Mivechi, NF .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6624-6633

← 1 2 3 4 →