Episodic memory in Alzheimer's disease: Separating response bias from discrimination

被引:65
作者
Budson, Andrew E.
Wolk, David A.
Chong, Hyemi
Waring, Jill D.
机构
[1] Edith Nourse Rogers Mem Vet Adm Hosp, Ctr Geriatr Res Educ & Clin, Bedford, MA 01730 USA
[2] Boston Univ, Sch Med, Alzheimers Dis Ctr, Dept Neurol, Boston, MA 02215 USA
[3] Brigham & Womens Hosp, Dept Neurol, Div Cognit & Behav Neurol, Boston, MA 02115 USA
[4] Univ Pittsburgh, Dept Neurol, Alzheimers Dis Res Ctr, Pittsburgh, PA USA
关键词
memory; Alzheimer's disease; response bias; discrimination;
D O I
10.1016/j.neuropsychologia.2006.05.024
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Most studies examining episodic memory in Alzheimer's disease (AD) have focused on patients' impaired ability to remember information, leading to poor discrimination between studied and unstudied items at test. Poor discrimination, however, can also be attributable to an abnormally high rate of false alarms. One cause of a high false alarm rate is an abnormally liberal response bias; that is, responding "old" too liberally to the test items. In the present study, discrimination and response bias were evaluated when participants were given a series of progressively longer study-test lists of unrelated words. As expected, patients with AD showed overall worse discrimination and a more liberal response bias compared with older adult controls. Critically, patients with AD also showed a more liberal response bias than older adults when discrimination was matched between the groups after performance was equated by giving the older adult controls a more difficult test than the patients with AD. This result confirms that the patients' abnormally liberal response bias is not simply attributable to their poor discrimination. Correlation analyses suggest that the patients' liberal response bias is related to the degree of their episodic memory deficit, which may in turn be related to the severity of their disease. Thus, our research suggests that as AD progresses two distinct abnormalities of episodic memory develop: worse discrimination and a more liberal response bias. Possible explanations of this liberal response bias in patients with AD are discussed. Published by Elsevier Ltd.
引用
收藏
页码:2222 / 2232
页数:11
相关论文
共 73 条
[1]   Amnesia and recognition memory: A re-analysis of psychometric data [J].
Aggleton, JP ;
Shaw, C .
NEUROPSYCHOLOGIA, 1996, 34 (01) :51-62
[2]  
[Anonymous], 2005, DETECTION THEORY USE
[3]   Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study [J].
Asahi, S ;
Okamoto, Y ;
Okada, G ;
Yamawaki, S ;
Yokota, N .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2004, 254 (04) :245-251
[4]   THE DECLINE OF WORKING MEMORY IN ALZHEIMERS-DISEASE - A LONGITUDINAL-STUDY [J].
BADDELEY, AD ;
BRESSI, S ;
DELLASALA, S ;
LOGIE, R ;
SPINNLER, H .
BRAIN, 1991, 114 :2521-2542
[5]   Preserved recognition in a case of developmental amnesia: Implications for the acquisition of semantic memory? [J].
Baddeley, AD ;
Vargha-Khadem, F ;
Mishkin, M .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2001, 13 (03) :357-369
[6]   The word-frequency mirror effect in young, old, and early-stage Alzheimer's disease: Evidence for two processes in episodic recognition performance [J].
Balota, DA ;
Burgess, GC ;
Cortese, MJ ;
Adams, DR .
JOURNAL OF MEMORY AND LANGUAGE, 2002, 46 (01) :199-226
[7]   Varying patterns of verbal recall, recognition, and response bias with progression of Alzheimer's disease [J].
Bartok, JA ;
Wilson, CS ;
Giordani, B ;
Keys, BA ;
Persad, CC ;
Foster, NL ;
Berent, S .
AGING NEUROPSYCHOLOGY AND COGNITION, 1997, 4 (04) :266-272
[8]   ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS [J].
BLESSED, G ;
TOMLINSON, BE ;
ROTH, M .
BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) :797-+
[9]   Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory [J].
Buckner, RL ;
Snyder, AZ ;
Shannon, BJ ;
LaRossa, G ;
Sachs, R ;
Fotenos, AF ;
Sheline, YI ;
Klunk, WE ;
Mathis, CA ;
Morris, JC ;
Mintun, MA .
JOURNAL OF NEUROSCIENCE, 2005, 25 (34) :7709-7717
[10]   When false recognition is unopposed by true recognition: Gist-based memory distortion in Alzheimer's disease [J].
Budson, AE ;
Daffner, KR ;
Desikan, R ;
Schacter, DL .
NEUROPSYCHOLOGY, 2000, 14 (02) :277-287